Search results for " GSH"

showing 3 items of 3 documents

Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery

2016

(1) Background: A new family of nanosystems able to discern between normal and tumor cells and to release a therapeutic agent in controlled way were synthetized by e-beam irradiation. This technique permits to obtain biocompatible, sterile, carboxyl-functionalized polyvinylpyrrolidone (PVP-co-acrylic acid) nanogels (NGs); (2) Methods: Here, we performed a targeting strategy based on the recognition of over-expressed proteins on tumor cells, like the folate receptor. The selective targeting was demonstrated by co-culture studies and flow cytometry analysis, using folate conjugated NGs. Moreover, nanoparticles were conjugated to a chemotherapeutic drug or to a pro-apoptotic siRNA through a gl…

PVPPharmaceutical ScienceNanogels02 engineering and technologyPharmacology01 natural sciencesAntioxidantsAnalytical Chemistryfolate-targetingPolyethylene GlycolsNanogelchemistry.chemical_compoundMiceRNA interferenceNeoplasmsDrug DiscoveryFluorescence microscopePolyethyleneimineRNA Small InterferingCytotoxicitymedicine.diagnostic_testPovidone021001 nanoscience & nanotechnologyControlled releaseCell biologyChemistry (miscellaneous)Folate receptorMolecular Medicinee-beamGSH-responsive release0210 nano-technologyOxidation-Reduction010402 general chemistrydoxorubicinArticleFlow cytometryFolic AcidCell Line TumormedicineAnimalsHumansPhysical and Theoretical ChemistryParticle SizeOrganic ChemistryGlutathione0104 chemical scienceschemistryPVP; nanogels; e-beam; folate-targeting; doxorubicin; siRNA; GSH-responsive releasesiRNACancer cellNIH 3T3 CellsNanoparticlesSettore CHIM/07 - Fondamenti Chimici Delle TecnologieFolic Acid TransportersHeLa CellsMolecules
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Tumor and its microenvironment: a synergistic interplay.

2013

The mutual and interdependent interaction between tumor and its microenvironment is a crucial topic in cancer research. Recently, it was reported that targeting stromal events could improve efficacies of current therapeutics and prevent metastatic spreading. Tumor microenvironment is a "complex network" of different cell types, soluble factors, signaling molecules and extracellular matrix components, which orchestrate the fate of tumor progression. As by definition, cancer stem cells (CSCs) are proposed to be the unique cell type able to maintain tumor mass and survive outside the primary tumor at metastatic sites. Being exposed to environmental stressors, including reactive oxygen species …

Cancer ResearchStromal cellEpithelial-Mesenchymal TransitionAngiogenesisCell SurvivalBiologyCancer stem cellCell MovementNeoplasmsmedicineTumor MicroenvironmentAnimalsHumansEpithelial–mesenchymal transitionNeoplasm MetastasisStem Cell NicheHypoxiaTumor microenvironmentNeovascularization Pathologicmedicine.diseaseAngiogenesis CAFs CAMs CRC CSCs ECM EMT GSH HIF Hypoxia MMPs ROS Tumor microenvironment VEGF cancer stem cells cancer-associated fibroblasts cancer-associated macrophages colorectal cancer epithelial mesenchymal transition extracellular matrix hypoxia-inducible factor matrix metalloproteinase reactive oxygen species reduced glutathione vascular endothelial growth factorPrimary tumorTumor progressionImmunologyCancer researchNeoplastic Stem CellsCancer-Associated FibroblastsOxidation-ReductionSignal Transduction
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Seasonal screening of AChE, GSH and gonad histology, in European sea bassDicentrarchus labraxL. reared in three different fish farms

2013

The aim of this work was to do a preliminary seasonal screening of ecotoxicological biomarkers in European sea bass Dicentrarchus labrax in three different fish farms, to know if the different location and typology can discriminate them. A set of selected biomarkers of xenobiotic exposure, such as acetylcholinesterase (AChE) activity, Glutathione (GSH) and gonad morphology were investigated seasonally in male European sea bass D. labrax (L.) reared in three different intensive farms: a land-based farm of cement tanks (T), an in-shore sea cages farm (C1) and an off-shore sea cages farm (C2). The results showed that both location and typology can discriminate AChE activity, GSH content and go…

Settore BIO/07 - EcologiaMaleGonadAchéanimal diseasesFish farmingZoologyAquaculturePlant ScienceBiochemistryAnalytical ChemistryEuropean sea bachemistry.chemical_compoundAquacultureGSHmedicineEuropean sea bass aquaculture AChE; GSH ovarian histologyAnimalsEuropean sea bassSea bassGonadsAnalysis of VariancebiologyAChE GSHbusiness.industryfungiOrganic Chemistryovarian histologyFishesGlutathionebiology.organism_classificationGlutathionelanguage.human_languageFisherymedicine.anatomical_structurechemistryAChE GSH; aquaculture; European sea bass; ovarian histologyAcetylcholinesteraselanguageAChEDicentrarchusXenobioticbusinessNatural Product Research
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